Stereoselective Growth of Small Molecule Patches on Nanoparticles

J Zhou; MN Creyer; A Chen; W Yim; RPM Lafleur; T He; Z Lin; M Xu; P Abbasi; J Wu; TA Pascal; F Caruso; JV Jokerst

Journal article

Stereoselective Growth of Small Molecule Patches on Nanoparticles

J Zhou, MN Creyer, A Chen, W Yim, RPM Lafleur, T He, Z Lin, M Xu, P Abbasi, J Wu, TA Pascal, F Caruso, JV Jokerst

Journal of the American Chemical Society | Published : 2021

DOI: 10.1021/jacs.1c04272

Download PDF

Abstract

Patchy nanoparticles featuring tunable surface domains with spatial and chemical specificity are of fundamental interest, especially for creating three-dimensional (3D) colloidal structures. Guided assembly and regioselective conjugation of polymers have been widely used to manipulate such topography on nanoparticles; however, the processes require presynthesized specialized polymer chains and elaborate assembly conditions. Here, we show how small molecules can form 3D patches in aqueous environments in a single step. The patch features (e.g., size, number, conformation, and stereoselectivity) are modulated by a self-polymerizable aromatic dithiol and comixed ligands, which indicates an auto..

View full abstract

University of Melbourne Researchers

Zhixing Lin Author

Frank Caruso Author

Related Projects (2)

ADVANCING NANOMEDICINE THROUGH PARTICLE TECHNOLOGY

This proposal will support the development of advanced particle systems to improve the delivery of medicines in neurological diseases, HIV, ..

ARC CENTRE OF EXCELLENCE IN CONVERGENT BIO–NANO SCIENCE AND TECHNOLOGY

The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control ..

Grants

Awarded by University of California, San Diego

Funding Acknowledgements

We thank Dr. Y. Cheng, Mr. C. Moore, Dr. Z. Jin, and Dr. H. Duan for helpful discussions. This work was performed in part at the San Diego Nanotechnology Infrastructure (SDNI) of University of California San Diego, a member of the National Nanotechnology Coordinated Infrastructure (NNCI), which is supported by the National Science Foundation (Grant ECCS1542148). This work was sponsored in part by the UC San Diego Materials Research Science and Engineering Center (UCSD MRSEC), supported by the National Science Foundation (Grant DMR-2011924). This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). M.N.C. acknowledges fellowship funding from T32 CA153915. R.P.M.L. acknowledges The Netherlands Organisation for Scientific Research for a Rubicon postdoctoral fellowship (project 019.182EN.034). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). J.V.J. acknowledges funding from NIH under DP2 HL137187 and NSF 1845683.